Ack... this thing is getting uglier with each new variant ! (there have been a few...)
Ok, first, follow this link and follow instructions so you can See hidden files and folders. Better print this out, as you won't be able to view this site once in Safe Mode. Next, follow these instructions to Reboot your computer in Safe Mode.
Now, run HijackThis! and fix these entries :
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Bar = http://mypoiskovik.com/sp.htm
R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://mypoiskovik.com/index.htm
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://mypoiskovik.com/index.htm
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = res://C:\WINDOWS\system32\tqivu.dll/sp.html#29126
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant = http://mypoiskovik.com/sp.htm
R1 - HKCU\Software\Microsoft\Internet Explorer\SearchURL,(Default) = http://mypoiskovik.com/index.htm
R3 - Default URLSearchHook is missing
O2 - BHO: (no name) - {50838896-9654-6D5F-8DD1-DC592611A0D7} - C:\WINDOWS\system32\apihm.dll (file missing)
O4 - HKLM\..\Run: [pwbzzejtuwun] C:\WINDOWS\System32\ewinmklx.exe
O4 - HKCU\..\Run: [Diow] C:\Documents and Settings\Vanessa\Application Data\eare.exe
O4 - HKCU\..\Run: [Fwevj] C:\WINDOWS\System32\rjerm.exe
O4 - Global Startup: winlgn.exe
O15 - Trusted Zone: *.05p.com
O15 - Trusted Zone: *.mt-download.com
O15 - Trusted Zone: *.my-internet.info
O15 - Trusted Zone: *.scoobidoo.com
O15 - Trusted Zone: *.searchmiracle.com
Still in Safe Mode, locate and delete these files (if found) :
C:\Documents and Settings\All Users\Start Menu\Programs\Startup\winlgn.exe <<< this file (make sure the spelling is correct on this one, as "winlogon.exe" is legit..)
C:\WINDOWS\System32\ewinmklx.exe <<< this file
C:\Documents and Settings\Vanessa\Application Data\eare.exe <<< this file
C:\WINDOWS\System32\rjerm.exe <<< this file
Ok, you can reboot normally. Scan with HijackThis! again, and post a new log. Good luck !